The process is simpler than most would realize.  Simply head over to your NPPES account at https://nppes.cms.hhs.gov/ and create an account or login. 

You can submit an address change request via your account there.  This is the most expedient way to make changes so we recommend this method.

Alternatively you can use the official form from CMS.gov to make these changes.  Here’s that form:  https://www.cms.gov/Medicare/CMS-Forms/CMS-Forms/downloads/cms10114.pdf

You’ll need to mail that completed form to:

NPI Enumerator,
P.O. Box 6059,
Fargo,
ND 58108-6059